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e2 see above  (MedChemExpress)


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    MedChemExpress e2 see above
    Fig. 3. Shedding of excess LDLR in PCSK9-deficient mice depends on estrogen and is achieved by metalloproteases. (A) Plasma levels of shed LDLR (sLDLR) were assessed in all mouse models and normalized to WT male levels. n = 4–5 mice. (B) sLDLR was measured for 28 h in WT and KO male mice after vehicle (Veh) or <t>E2</t> injection (50 μg/kg; n = 4–6 mice). (C) WT and KO female mice received an intraperitoneal injection of vehicle or <t>the</t> <t>metalloprotease</t> inhibitor BB-94 (12.5 mg/kg; n = 4–5 mice). Mean ± SEM were normalized to WT Veh value at t = 0 and set to 1. P values were determined using Mann-Whitney U test (A; non parametric data) and 2-way ANOVA followed by Tukey’s multiple comparisons test (B and C).
    E2 See Above, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 188 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/e2+see+above/Estradiol/pm35985474-62-5-25
    Average 97 stars, based on 188 article reviews
    e2 see above - by Bioz Stars, 2026-09
    97/100 stars

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    1) Product Images from "PCSK9 deficiency results in a specific shedding of excess LDLR in female mice only: Role of hepatic cholesterol."

    Article Title: PCSK9 deficiency results in a specific shedding of excess LDLR in female mice only: Role of hepatic cholesterol.

    Journal: Biochimica et biophysica acta. Molecular and cell biology of lipids

    doi: 10.1016/j.bbalip.2022.159217

    Fig. 3. Shedding of excess LDLR in PCSK9-deficient mice depends on estrogen and is achieved by metalloproteases. (A) Plasma levels of shed LDLR (sLDLR) were assessed in all mouse models and normalized to WT male levels. n = 4–5 mice. (B) sLDLR was measured for 28 h in WT and KO male mice after vehicle (Veh) or E2 injection (50 μg/kg; n = 4–6 mice). (C) WT and KO female mice received an intraperitoneal injection of vehicle or the metalloprotease inhibitor BB-94 (12.5 mg/kg; n = 4–5 mice). Mean ± SEM were normalized to WT Veh value at t = 0 and set to 1. P values were determined using Mann-Whitney U test (A; non parametric data) and 2-way ANOVA followed by Tukey’s multiple comparisons test (B and C).
    Figure Legend Snippet: Fig. 3. Shedding of excess LDLR in PCSK9-deficient mice depends on estrogen and is achieved by metalloproteases. (A) Plasma levels of shed LDLR (sLDLR) were assessed in all mouse models and normalized to WT male levels. n = 4–5 mice. (B) sLDLR was measured for 28 h in WT and KO male mice after vehicle (Veh) or E2 injection (50 μg/kg; n = 4–6 mice). (C) WT and KO female mice received an intraperitoneal injection of vehicle or the metalloprotease inhibitor BB-94 (12.5 mg/kg; n = 4–5 mice). Mean ± SEM were normalized to WT Veh value at t = 0 and set to 1. P values were determined using Mann-Whitney U test (A; non parametric data) and 2-way ANOVA followed by Tukey’s multiple comparisons test (B and C).

    Techniques Used: Clinical Proteomics, Injection, MANN-WHITNEY

    Related Articles

    Injection:

    Article Title: PCSK9 deficiency results in a specific shedding of excess LDLR in female mice only: Role of hepatic cholesterol.
    Article Snippet: Plasma sLDLR concentration was determined with the DuoSet ELISA (R&D Systems). .. Male mice were treated with E2 (see above) and male or female mice were treated with the metalloprotease inhibitors BB-94 and ZLDI-8 resuspended in DMSO (MedChemExpress, Princeton, NJ) and diluted ≥10-fold in corn oil before intraperitoneal injection. ..



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    e2 see above  (MedChemExpress)
    97
    MedChemExpress e2 see above
    Fig. 3. Shedding of excess LDLR in PCSK9-deficient mice depends on estrogen and is achieved by metalloproteases. (A) Plasma levels of shed LDLR (sLDLR) were assessed in all mouse models and normalized to WT male levels. n = 4–5 mice. (B) sLDLR was measured for 28 h in WT and KO male mice after vehicle (Veh) or <t>E2</t> injection (50 μg/kg; n = 4–6 mice). (C) WT and KO female mice received an intraperitoneal injection of vehicle or <t>the</t> <t>metalloprotease</t> inhibitor BB-94 (12.5 mg/kg; n = 4–5 mice). Mean ± SEM were normalized to WT Veh value at t = 0 and set to 1. P values were determined using Mann-Whitney U test (A; non parametric data) and 2-way ANOVA followed by Tukey’s multiple comparisons test (B and C).
    E2 See Above, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/e2+see+above/Estradiol/pm35985474-62-5-25
    Average 97 stars, based on 1 article reviews
    e2 see above - by Bioz Stars, 2026-09
    97/100 stars
    		  Buy from Supplier

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    Fig. 3. Shedding of excess LDLR in PCSK9-deficient mice depends on estrogen and is achieved by metalloproteases. (A) Plasma levels of shed LDLR (sLDLR) were assessed in all mouse models and normalized to WT male levels. n = 4–5 mice. (B) sLDLR was measured for 28 h in WT and KO male mice after vehicle (Veh) or E2 injection (50 μg/kg; n = 4–6 mice). (C) WT and KO female mice received an intraperitoneal injection of vehicle or the metalloprotease inhibitor BB-94 (12.5 mg/kg; n = 4–5 mice). Mean ± SEM were normalized to WT Veh value at t = 0 and set to 1. P values were determined using Mann-Whitney U test (A; non parametric data) and 2-way ANOVA followed by Tukey’s multiple comparisons test (B and C).

    Journal: Biochimica et biophysica acta. Molecular and cell biology of lipids

    Article Title: PCSK9 deficiency results in a specific shedding of excess LDLR in female mice only: Role of hepatic cholesterol.

    doi: 10.1016/j.bbalip.2022.159217

    Figure Lengend Snippet: Fig. 3. Shedding of excess LDLR in PCSK9-deficient mice depends on estrogen and is achieved by metalloproteases. (A) Plasma levels of shed LDLR (sLDLR) were assessed in all mouse models and normalized to WT male levels. n = 4–5 mice. (B) sLDLR was measured for 28 h in WT and KO male mice after vehicle (Veh) or E2 injection (50 μg/kg; n = 4–6 mice). (C) WT and KO female mice received an intraperitoneal injection of vehicle or the metalloprotease inhibitor BB-94 (12.5 mg/kg; n = 4–5 mice). Mean ± SEM were normalized to WT Veh value at t = 0 and set to 1. P values were determined using Mann-Whitney U test (A; non parametric data) and 2-way ANOVA followed by Tukey’s multiple comparisons test (B and C).

    Article Snippet: Male mice were treated with E2 (see above) and male or female mice were treated with the metalloprotease inhibitors BB-94 and ZLDI-8 resuspended in DMSO (MedChemExpress, Princeton, NJ) and diluted ≥10-fold in corn oil before intraperitoneal injection.

    Techniques: Clinical Proteomics, Injection, MANN-WHITNEY